Scientific Publications

Review Articles
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2016

Mckee AC, Alosco ML, Huber BR. Repetitive Head Impacts and Chronic Traumatic Encephalopathy. Neurosurg Clin N Am. 2016;27(4):529-35. [PDF]

Huber BR, Alosco ML, Stein TD, Mckee AC. Potential Long-Term Consequences of Concussive and Subconcussive Injury. Phys Med Rehabil Clin N Am. 2016;27(2):503-11. [PDF]

2015

Montenigro, P.H., Bernick, C, Cantu, R.C. Clinical Features of Repetitive Traumatic Brain Injury and Chronic Traumatic Encephalopathy. Brain Pathology, 2015. [PDF]

Riley, D.O., Robbins, C.A., Cantu, R.C., Stern, R.A. Chronic Traumatic Encephalopathy: Contributions from the Boston University Center for the Study of Traumatic Encephalopathy. Brain Injury, 2015.

2012

Baugh CM, Stamm JM, Riley DO, Gavett BE, Shenton ME, Lin A, Nowinski CJ, Cantu RC, McKee AC, Stern RA. Chronic traumatic encephalopathy: Neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging and Behavior, 2012.

2011

Gavett BE, Stern RA, McKee AC. Chronic Traumatic Encephalopathy: A Potential Late Effect of Sport-Related Concussive and Subconcussive Head Trauma. Clinics in Sports Medicine, 30(1), 179-188, 2011. [PDF]

Gavett BE, Cantu RC, Shenton M, Lin AP, Nowinski CJ, McKee AC, and Stern RA. Clinical appraisal of chronic traumatic encephalopathy: current perspectives and future directions. Current Opinion in Neurology, 24, 525-531, 2011. [PDF]

Stern RA, Riley DO, Daneshvar DH, Nowinski CJ, Cantu RC, McKee AC. Long-term Consequences of Repetitive Brain Trauma: Chronic Traumatic Encephalopathy. Phys Med Rehabil Clin N Am, 3, S460-S467, October 2011. [PDF]

Stern, RA, Gavett BE, Baugh C, Nowinski CJ, Cantu RC, McKee AC. Recurrent sports-related traumatic brain injury and tauopathy. Edited by M. Oria and J. Erdman. Washington, DC: The National Academies Press. 2011

2010

Gavett BE, Stern RA, Cantu RC, Nowinski CJ, McKee AC. Mild traumatic brain injury: a risk factor for neurodegeneration. Alzheimer’s Research & Therapy 2010, 2:18. [PDF]

Chronic Traumatic Encephalopathy
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2017

Alosco ML, Mez J, Kowall NW, et al. Cognitive Reserve as a Modifier of Clinical Expression in Chronic Traumatic Encephalopathy: A Preliminary Examination. J Neuropsychiatry Clin Neurosci. 2017;29(1):6-12. [PDF]

2016

Mufson EJ, Perez SE, Nadeem M, et al. Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study. Brain Inj. 2016;30(12):1399-1413. [PDF]

Woerman AL, Aoyagi A, Patel S, et al. Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells. Proc Natl Acad Sci USA. 2016;113(50):E8187-E8196. [PDF]

Cherry JD, Tripodis Y, Alvarez VE, et al. Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2016;4(1):112. [PDF]

Mez J, Solomon TM, Daneshvar DH, Stein TD, Mckee AC. Pathologically Confirmed Chronic Traumatic Encephalopathy in a 25-Year-Old Former College Football Player. JAMA Neurol. 2016;73(3):353-5. [PDF]

Mckee AC, Cairns NJ, Dickson DW, et al. The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. Acta Neuropathol. 2016;131(1):75-86. [PDF]

2015

Stein, T.D., Montenigro, P.H., Alvarez, V.E., Xia, W., Crary, J.F., Tripodis, Y., Daneshvar, D.H., Mez, J., Solomon, T., Meng, G., Kubilus, C.A., Cormier, K.A., Meng, S., Babcock, K., Kiernan, P., Murphy, L., Nowinski, C.J., Martin, B., Dixon, D., Stern, R.A., Cantu, R.C., Kowall, N.W., McKee, A.C., 2015. Beta-amyloid deposition in chronic traumatic encephalopathy. Acta Neuropathol 2015 Jul;130(1):21-34. [PDF]

Lin AP, Ramadan S, Stern RA, Box HC, Nowinski CJ, Ross BD, Mountford CE. Changes in the neurochemistry of athletes with repetitive brain trauma: preliminary results using localized correlated spectroscopy. Alzheimers Res. Ther. 2015 Mar 15;7(1):13. [PDF]

2014

McKee AC, Robinson ME. Military-related traumatic brain injury and neurodegeneration. Alzheimers Dement. 2014 Jun;10(3 Suppl):S242-53. [PDF]

2013

Robert A. Stern, Daniel H. Daneshvar, Christine M. Baugh, Daniel R. Seichepine, Philip H. Montenigro, David O. Riley, Nathan G. Fritts, Julie M. Stamm, Clifford A. Robbins, Lisa McHale, Irene Simkin, Thor D. Stein, Victor E. Alvarez, Lee E. Goldstein, Andrew E. Budson, Neil W. Kowall, Christopher J. Nowinski, Robert C. Cantu, and Anne C. McKee. Clinical Presentation of Chronic Traumatic Encephalopathy. Neurology, 2013 [PDF]

2012

McKee AC, Stern RA, Nowinski CJ, Stein TD, Daneshvar DH, Alvarez VE, Lee HS, Hall GF, Wojtowicz SM, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldsteing LE, Kowall NW, Cantu RC. The spectrum of disease in chronic traumatic encephalopathy. Brain. 2012 December 2; 135(12). [PDF]

Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med. 2012, 4:134ra60. [PDF]

2010

McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perl D, Hedley-Whyte ET, Price B, Sullivan C, Morin P, Lee HS, Kubilus CA, Daneshvar DH, Wulff M, Budson AE. TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy. J Neuropath Exp Neurol, 2010; 69(9): 918-929. [PDF]

Sports Related Concussion
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2013

Seichepine, DR, Stamm, JM, Daneshvar, DH, Riley, DO, Baugh, CM, Gavett, BE, Tripodis, Y, Martin, B, Chaisson, C, McKee, AC, Cantu, RC, Nowinski, CJ, & Stern, RA (in press). Profile of Self-reported Problems with Executive Functioning in College and Professional Football Players. Journal of Neurotrauma, 2013; 30: 1299-1304. [PDF]

2011

Daneshvar DH, Riley DO, Nowinski CJ, McKee AC, Stern RA, Cantu RC. Long-Term Consequences: Effects on Normal Development Profile After Concussion. Phys Med Rehabil Clin N Am, 22, 603-670, October 2011. [PDF]

Daneshvar DH, Baugh CM, Nowinski CJ, McKee AC, Stern RA, Cantu RC. Helmets and Mouth Guards: The Role of Personal Equipment in Preventing Sport-Related Concussions. Clinics in Sports Medicine, 30 (1), 145-163, January 2011. [PDF]

Daneshvar DH, Nowinski CJ, McKee AC, Cantu RC. The Epidemiology of Sports-Related Concussion. Clinics in Sports Medicine, 30(1), 1-17, January 2011. [PDF]

Concussion Education
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2017

Stern RA, Seichepine D, Tschoe C, et al. Concussion Care Practices and Utilization of Evidence-Based Guidelines in the Evaluation and Management of Concussion: A Survey of New England Emergency Departments. J Neurotrauma. 2017;34(4):861-868. [PDF]

2016

Koerte IK, Mayinger M, Muehlmann M, et al. Cortical thinning in former professional soccer players. Brain Imaging Behav. 2016;10(3):792-8. [PDF]

2015

Kroshus E, Baugh CM, Daneshvar DH, Nowinski CJ, Cantu RC. Concussion reporting intention: a valuable metric for predicting reporting behavior and evaluating concussion education. Clin J Sport Med. 2015 May;25(3):243-7 [PDF]

2014

Robbins, C.A., Daneshvar, D.H., Picano, J.D., Gavett, B.E., Baugh, C.M., Riley, D.O., Nowinski, C.J., McKee, A.C., Cantu, R.C., Stern, R.A. Self-Reported Concussion History: Impact of Providing a Definition of Concussion. Open Access Journal of Sports Medicine. 2014 May 7;5:99-103. [PDF]

2013

Kroshus E, Daneshvar DH, Baugh CM, et al. NCAA concussion education in ice hockey: an ineffective mandate. Br J Sports Med. Published online first: August 2013. [PDF]

2012

Bagley, A.F.,Daneshvar DH, Schanker BD, Zurakowski D, Dʼhemecourt CA, Nowinski CJ, Cantu RC, Goulet K. Effectiveness of the SLICE Program for Youth Concussion Education. Clin J Sport Med. September 2012. 22(5): p. 385-389. [PDF]

2009

McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee H-Y, Kubilus CA, Stern RA.Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy following Repetitive Head Injury.  J Neuropath Exp Neurol, 2009; 68(7): 709-735. [PDF]

Selection of Dr. Cantu's Publications
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2014

Collins CL, Fletcher EN, Fields, SK, Kluchurosky L, Rohrkemper MK, Comstock RD, Cantu RC, Neck Strength: A Protective Factor Reducing Risk for Concussion in High School Sports: J Primary Prevent; June 2014:35:3

Slobounov S, Bazarian J, Bigler E, Cantu R, Hallett M, Harbaugh R, Hovda D, Mayer AR, Nuwer MR, Kou Z, Lazzarino G, Papa L, Vagnozzi R, Sport-Related concussion: Ongoing Debate: BR J Sports Med; January 2014: 48:2:75-76.

Broglio SP, Cantu RC, Gioia GA, Guskiewicz KM, Kutcher J, Palm M, Valovich McLeod TC, National Athletic Trainers’ Association Position Statement: Management of Sport Concussion: Journal of Athletic Training; 2014;49(2):245-265.

2013

Cantu RC, Role of Diffusion Tensor Imaging MRI in Detecting Brain Injury in Asymptomatic Contact Athletes: World Neurosurgery; December 2013;5:792-793.

Cantu RC, The Role of the Neurologist in Concussions When to Tell Your Patient to Stop: Jama Neurology; October 2013;Jamaneurology.com;E1-E2.

Makdissi M, Cantu RC, Johnston KM, McCrory P, Meeuwisse WH: The difficult Concussion Patient: What is the Best Approach to Investigation and Management of Persistent (>10 days) Postconcussive Symptoms?: Br J Sports Med 2013;47:308-313 doi:10.1136/bjsports-2013-092255.

Putukian M, Raftery M, Guskiewicz K, Herring S, Aubry M, Cantu RC, Molloy, Onfield Assessment of Concussion in the adult athlete: Br J Sports Med 2013;47:285-288 doi:10.1136/bjsports-2013-092158.

Cantu, RC, Li Y, Abdulhamid M, Chin L, Return to Play After Cervical Spine Injury in Sports, Current Sports Medicine Reports, Jan/Feb 2013;12 (1): 14-17.

McCrory P, Meeuvisse WH, Aubry M, Cantu B, et al, Dvorak J, Echemendia RJ, Engebretsen L, Johnston K, Kutcher JS, Raftery M, Sills A, Benson BW, Davis GA, Ellenbogen RG, Guskiewicz K, Herring SA, Iverson GL, Jordan BD, Kissick J, McCrea M, McIntosh AS, Maddocks D, Makdiss M, Purcell L, Putukian M, Schneider K, Tator CH, Turner M: Consensus Statement on Concussion in Sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012: Br J Sports Med 2013;47:250-258 doi:10.1136/bjsports-2013-092313.

2011

Chin LS, Toshkezi G, Cantu RC, Traumatic Encephalopathy Related to Sports Injury, US Neurology, 2011;7(1):33-6.

Chin LS, Jayarao M, Cantu RC: Inside Sports-Related Head Injury: Tau Inclusion Bodies and Proteins in a Tangle. Neurosurgeon, 2011;20(1):4-7.

Thomas M, Haas, TS, Doerer, JJ, Hodges JS, Aicher BO, Garberich RF, Mueller FO, Cantu RC, Maron BJ: Epidemiology of Sudden Death in Young, Competitive Athletes Due to Blunt Trauma. Pediatrics July 2011.

2010

Cantu RC: Is Helmet Design the Answer to Concussion in Sports. Active Voice Bulletin ACSM, September 2010.

Cantu RC: World Cup Soccer; A Major League Soccer Superstar’s Career-Ending Injury, Concussion; and World Neurosurgery: A Common Thread. World Neurosurgery August/September 2010;74(2/3):224-225.

Jayarao M, Chin L, Cantu R. Boxing-Related Head Injuries. The Physician and Sportsmedicine. October 2010;(3):0091-3847.

Cantu RC, Guskiewicz K, Register-Mhialik JK. A Retrospective Clinical Analysis of Moderate to Severe Athletic Concussions. PM&R. December 2010;(2)12:1088-1093.

Mihalik JP, Blackburn JT, Greenwald RM, Cantu RC, Marshall SW, Guskiewicz KM. Collision type and player anticipation affect head impact severity among youth ice hockey players. Pediatrics. June 2010;125(6):e1394-401.

Echlin PS, Tator CH, Cusimano MD, Cantu RC, Taunton JE, Upshur RE, Czarnota M, Hall CR, Johnson AM, Forwell LA, Driediger M, Skopelja EN. Return to play after an initial or recurrence concussion in a prospective study of physician-observed junior ice hockey concussions: implications for return to play after a concussion. Neurosurg Focus 2010;29(5):E5.

Echlin PS, Johnson AM, Riverin S, Tator CH, Cantu RC, Cusimano MD, Taunton JE, Upshur RE, Hall CR, Forwell LA, Skopelja EN. A prospective study of concussion education in 2 junior ice hockey teams: implications for sports concussion education. Neurosurg Focus 2010;29(5):E6.

Echlin PS, Tator CH, Cusimaon MD, Cantu RC, Taunton JE, Upshur RE, Hall CR, Johnson AM, Forwell LA, Skopelja EN. A prospective study of physician-observed concussions during junior ice hockey: implications for incidence rates. Neurosurg Focus 2010;29(5):E4.

Cantu RC, Gean A. Second Impact Syndrome and a Thin Subdural Hematoma: An Uncommon Catastrophic Result of Repetitive Head Injury With a Characteristic Imaging Appearance. J Neurotrauma 2010;27:1-8.

Mihalik JP, Greenwalk RM, Blackburn JT, Cantu RC, Marshall SW, Guskiewicz KM. The effect of infraction type on head impact severity in youth ice hockey. Med Sci Sports Exer. 2010;42:1431-1438

2009

Cantu, R: Consensus Statement on Concussion in Sport – The 3rd International Conference on Concussion, Zurich, November 2008. Neurosurgery 64(5):786-787, 2009.

Cantu RC: Commentary When to Disqualify an Athlete After a Concussion, Current Sports Medicine Reports 8:6-7,2009.

Cantu RC, Mueller FO. The prevention of catastrophic head and spine injuries in high school and college sports. Br J Sports Med. 2009;43:981-986.

McCrory JP, Meeuwisse W, Johnston K, Dvorak J, Aubry M, Mallow M, Cantu R. Consensus statement on concussion in sports – the Third International Conference on Concussion in Sport held in Zurich, November 2008, Phy Sportsmed. 2009;37:141-159.

Cantu RC: Commentary When to Disqualify an Athlete After a Concussion, Current Sports Medicine Reports 8:6-7,2009.

Cantu, R: Consensus Statement on Concussion in Sport – The 3rd International Conference on Concussion, Zurich, November 2008. Neurosurgery 64(5):786-787, 2009.

2008

Terrell, T, Bostick, R, Abramson, Xie, D, R, Barfield, W, Cantu, R, Stanek, M, Ewing, T. APOE, APOE Promoter, and Tau Genotypes and Risk for Concussion in College Athletes. Clinical Journal of Sport Medicine 18:10-17, 2008.

Davis G, Ugokwe K. Roger EP, Benzel EC, Cantu RC, Rogers M, Dvorak J, McCrory P: Br J Sports Med June 2008

2007

Cantu RC, Detection of postconcussion abnormalities after injury in young athletes. Clin J Sport Med 2007;17(5):435-436.

Standaert CJ, Herring SA, Cantu RC: Expert Opinion and Controversies in Sports and Musculoskeletal Medicine: Concussion in the Young Athlete. Arch Phys Med Rehabil; 2007;88:1077-1079.

Cantu RC, Herring SA, Putukian M: Concussion: Letter to the Editor. NEJM 2007;356(17):1787.

In Press

Montenigro PH, Baugh CM, Daneshvar DH, Mez J, Budson AE, Au R, Katz D, Cantu RC, Stern RA, Clinical Subtypes of Chronic Traumatic Encephalopathy: Alzheimer’s Research and Therapy; (in press)

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